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Chester A Metcalf Selected Research

AP23848

7/2005In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit.

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Chester A Metcalf Research Topics

Disease

9Neoplasms (Cancer)
07/2022 - 09/2003
5Bone Diseases (Bone Disease)
10/2006 - 01/2002
4BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
06/2010 - 10/2004
4Osteoporosis
10/2006 - 09/2003
3Bone Resorption
10/2006 - 09/2003
2Carcinoma (Carcinomatosis)
09/2006 - 02/2005
2Neoplasm Metastasis (Metastasis)
12/2005 - 09/2003
1Ovarian Neoplasms (Ovarian Cancer)
09/2006
1Adenocarcinoma
12/2005
1Systemic Mastocytosis
07/2005
1Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor)
07/2005
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
07/2005
1Colonic Neoplasms (Colon Cancer)
02/2005

Drug/Important Bio-Agent (IBA)

8src-Family KinasesIBA
10/2006 - 01/2002
6Phosphotransferases (Kinase)IBA
06/2010 - 01/2002
3EnzymesIBA
10/2006 - 09/2003
2Focal Adhesion Protein-Tyrosine KinasesIBA
07/2022 - 02/2005
2Imatinib Mesylate (Gleevec)FDA Link
11/2009 - 06/2006
2Diphosphonates (Bisphosphonates)IBA
10/2006 - 09/2003
2AP23846IBA
09/2006 - 12/2005
2Adenosine Triphosphate (ATP)IBA
12/2005 - 09/2003
1Therapeutic UsesIBA
11/2019
1cabazitaxelFDA Link
11/2019
1Antineoplastic Agents (Antineoplastics)IBA
11/2019
1hexanoic acid (hexanoate)IBA
11/2019
1Dasatinib (BMS 354825)FDA Link
11/2009
1nilotinibFDA Link
11/2009
1ponatinibIBA
11/2009
1Docetaxel (Taxotere)FDA Link
09/2006
1Proliferating Cell Nuclear Antigen (PCNA)IBA
09/2006
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
09/2006
1Interleukin-8 (Interleukin 8)IBA
12/2005
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
12/2005
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
07/2005
1AP23848IBA
07/2005
1AP23464IBA
07/2005
1Proteins (Proteins, Gene)FDA Link
02/2005
1bcr-abl Fusion ProteinsIBA
10/2004
1AP22408IBA
09/2003
1PurinesIBA
09/2003
1LigandsIBA
09/2003
1AP23236IBA
09/2003
1Zoledronic Acid (Zometa)FDA Link
09/2003
1Alendronate (Alendronate Sodium)FDA LinkGeneric
09/2003
1Protein Kinases (Protein Kinase)IBA
01/2002

Therapy/Procedure

4Therapeutics
11/2009 - 09/2003